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BBBdetect identifies brain regions with vascular dysfunction

This patent-protected software measures leakage of the brain's blood vessels in conditions such as traumatic brain injury, epilepsy, dementia, depression, and aging.​​​​

BBBdetect's measures of vascular leakage

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Rate of blood vessel leakage in the brain

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Brain regions with leaky blood vessels

PUBLICATIONS

  1. Imaging blood-brain barrier dysfunction in drug-resistant epilepsy: A multi-center study.
    Epilepsia 2025.
     

  2. Restoration of blood brain barrier integrity post neurosurgical resection in drug resistant epilepsy.
    Epilepsy & Behavior 2025.
    ​​

  3. Blood-brain barrier disruption and sustained systemic inflammation in individuals with long COVID-associated cognitive impairment.
    Nature neuroscience 2024.
     

  4. Evidence for interictal blood-brain barrier dysfunction in people with epilepsy.
    Epilepsia. 2024.
     

  5. Atypical paroxysmal slow cortical activity in healthy adults: Relationship to age and cognitive performance.
    Neurobiology of Aging. 2024.
     

  6. Cortical Plasticity is associated with Blood-Brain-Barrier Modulation.
    eLife. 2024.
     

  7. ​Quantitative analysis of magnetic resonance images for characterization of blood-brain barrier dysfunction in dogs with brain tumors.
    Journal of Veterinary Internal Medicine. 2023.
     

  8. Neuro-psychiatric symptoms in directly and indirectly blast exposed civilian survivors of urban missile attacks.
    BMC Psychiatry. 2023.
     

  9. Blood-Brain Barrier Dysfunction and Exposure to Head Impacts in University Football Players​.
    Clinical J Sport Medicine. 2023.
     

  10. Reversal of insulin resistance is associated with repair of blood-brain barrier dysfunction and remission in a patient with treatment-resistant bipolar depression.
    Bipolar Disorders. 2022.
    ​​​

  11. Concussion susceptibility is mediated by spreading depolarization-induced neurovascular dysfunction.
    Brain. 2022.
     

  12. Blood-brain barrier leakage in systemic lupus erythematosus is associated with gray matter loss and cognitive impairment.
    Ann Rheum Dis. 2020.
     

  13. Slow blood-to-brain transport underlies enduring barrier dysfunction in American football players.
    Brain. 2020.
     

  14. Blood-brain barrier imaging as a potential biomarker for bipolar disorder progression.
    Neuroimage Clinical. 2020.
     

  15. Dynamic Blood-Brain Barrier Regulation in Mild Traumatic Brain Injury.
    J Neurotrauma. 2020.
     

  16. Early blood-brain barrier dysfunction predicts neurological outcome following aneurysmal subarachnoid hemorrhage.
    EBioMedicine. 2019.
     

  17. Blood-brain barrier dysfunction in canine epileptic seizures detected by dynamic contrast-enhanced magnetic resonance imaging.
    Epilepsia. 2019.
     

  18. Blood-Brain Barrier Leakage: A New Biomarker in Transient Ischemic Attacks.
    Stroke. 2019.
     

  19. Concussion, microvascular injury, and early tauopathy in young athletes after impact head injury and an impact concussion mouse model.
    Brain. 2018.
     

  20. Imaging Blood-Brain Barrier Dysfunction in Football Players.
    JAMA Neurology. 2014.
     

  21. Blood-brain barrier imaging in human neuropathologies.
    Arch Med Res. 2014. 
     

  22. Blood-brain barrier disruption in post-traumatic epilepsy.
    A. J Neurol Neurosurg Psychiatry. 2008.
     

  23. Opening of the blood-brain barrier preceding cortical edema in a severe attack of FHM type II.
    Neurology. 2005.
     

  24. Focal cortical dysfunction and blood-brain barrier disruption in patients with Postconcussion syndrome.
    J Clin Neurophysiol. 2005.

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