top of page


The brain's blood vessels are extremely important for proper brain function.


The brain’s small blood vessels can get injured in many ways, including:

When these blood vessels fail to properly heal, they can lead to:

EMAGIX has developed a tool for detecting injured blood vessels in the brain using MRI.


This method was validated in a series of clinical studies, demonstrating the ability to:

  1. Detect blood vessels that are abnormally leaky

  2. Identify patients at risk of depression and cognitive decline​

  3. Evaluate the efficacy of new drugs


  1. Blood-Brain Barrier Dysfunction and Exposure to Head Impacts in University Football Players​.
    Jones C, Kamintsky L, Parker E, Kureshi N, Audas L, Wilson L, Champagne AA, Boulanger M, DiStefano V, Fenerty L, Bowen C, Beyea SD, Atkinson C, Clarke DB, Freidman A. Clinical J Sport Medicine. 2023


  2. Reversal of insulin resistance is associated with repair of blood-brain barrier dysfunction and remission in a patient with treatment-resistant bipolar depression.
    Calkin C, Kamintsky L, Freidman A. Bipolar Disorders. 2022.

  3. Concussion susceptibility is mediated by spreading depolarization-induced neurovascular dysfunction.
    Parker E, Aboghazleh R, Mumby G, Veksler R, Ofer J, Newton J, Smith R, Kamintsky L, Jones CMA, O'Keeffe E, Kelly E, Doelle K, Roach I, Yang LT, Moradi P, Lin JM, Gleason AJ, Atkinson C, Bowen C, Brewer KD, Doherty CP, Campbell M, Clarke DB, van Hameren G, Kaufer D, Friedman A. Brain. 2022.


  4. Blood-brain barrier leakage in systemic lupus erythematosus is associated with gray matter loss and cognitive impairment.
    Kamintsky L, Beyea SD, Fisk JD, Hashmi JA, Omisade A, Calkin C, Bardouille T, Bowen C, Quraan M, Mitnitski A, Matheson K, Friedman A, Hanly JG. Ann Rheum Dis. 2020.


  5. Slow blood-to-brain transport underlies enduring barrier dysfunction in American football players.
    Veksler R, Vazana U, Serlin Y, Prager O, Ofer J, Shemen N, Fisher AM, Minaeva O, Hua N, Saar-Ashkenazy R, Benou I, Riklin-Raviv T, Parker E, Mumby G, Kamintsky L, Beyea S, Bowen CV, Shelef I, O'Keeffe E, Campbell M, Kaufer D, Goldstein LE, Friedman A. Brain. 2020.


  6. Blood-brain barrier imaging as a potential biomarker for bipolar disorder progression.
    Kamintsky L, Cairns KA, Veksler R, Bowen C, Beyea SD, Friedman A, Calkin C. Neuroimage Clinical. 2020.


  7. Dynamic Blood-Brain Barrier Regulation in Mild Traumatic Brain Injury.
    O'Keeffe E, Kelly E, Liu Y, Giordano C, Wallace E, Hynes M, Tiernan S, Meagher A, Greene C, Hughes S, Burke T, Kealy J, Doyle N, Hay A, Farrell M, Grant GA, Friedman A, Veksler R, Molloy MG, Meaney JF, Pender N, Camarillo D, Doherty CP, Campbell M. J Neurotrauma. 2020.


  8. Early blood-brain barrier dysfunction predicts neurological outcome following aneurysmal subarachnoid hemorrhage.
    Lublinsky S, Major S, Kola V, Horst V, Santos E, Platz J, Sakowitz O, Scheel M, Dohmen C, Graf R, Vatter H, Wolf S, Vajkoczy P, Shelef I, Woitzik J, Martus P, Dreier JP, Friedman A. EBioMedicine. 2019.


  9. Blood-brain barrier dysfunction in canine epileptic seizures detected by dynamic contrast-enhanced magnetic resonance imaging.
    Hanael E, Veksler R, Friedman A, Bar-Klein G, Senatorov VV Jr, Kaufer D, Konstantin L, Elkin M, Chai O, Peery D, Shamir MH. Epilepsia. 2019.


  10. Blood-Brain Barrier Leakage: A New Biomarker in Transient Ischemic Attacks.
    Serlin Y, Ofer J, Ben-Arie G, Veksler R, Ifergane G, Shelef I, Minuk J, Horev A, Friedman A. Stroke. 2019.


  11. Blood-brain barrier imaging in human neuropathologies.
    Veksler R, Shelef I, Friedman A. Arch Med Res. 2014. 


  12. Blood-brain barrier disruption in post-traumatic epilepsy.
    Tomkins O, Shelef I, Kaizerman I, Eliushin A, Afawi Z, Misk A, Gidon M, Cohen A, Zumsteg D, Friedman A. J Neurol Neurosurg Psychiatry. 2008.


  13. Opening of the blood-brain barrier preceding cortical edema in a severe attack of FHM type II.
    Dreier JP, Jurkat-Rott K, Petzold GC, Tomkins O, Klingebiel R, Kopp UA, Lehmann-Horn F, Friedman A, Dichgans M. Neurology. 2005.


  14. Focal cortical dysfunction and blood-brain barrier disruption in patients with Postconcussion syndrome.
    Korn A, Golan H, Melamed I, Pascual-Marqui R, Friedman A. J Clin Neurophysiol. 2005.



bottom of page